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Nano-antibody Service Facility (NSF)

The Nano-antibody Service Facility is technology platform of the University of Zurich established to provide production and selection of highly specific single-domain camelid antibody fragments, also known as nanobodies or VHH (NANOBODIES® compounds is a registered trademark of Ablynx N.V.), to Life Science Community in Zurich and region.

 

We are a non-profit service platform with many years experience in phage-display and selection of binders, offering production of immune nano-antibody libraries at costs attractive for researchers.

 

The Nano-antibody Service Facility offers its services to members of the University and the University Hospitals as well as ETH research groups. We are open for collaboration with other academic groups in Switzerland and abroad. 

 

Industry partners interested in nano-antibody technology are welcome to contact us. 

Weiterführende Informationen

Location

AgroVet-Strickhof

Eschikon 27, EHB/EHD F22

CH-8315 Lindau

 

Recent publication "Protein Binder Toolbox for Studies of Solute Carrier Transporters" by the ReSOLUTE consortium shows the importance of nano-antibodies in advancing SLC transporters research. Developed by our platform, these recombinant antibody fragments prove to be the best binder choice for targeting solute carrier proteins.

Follow the link below to discover how recombinant antibodies are redefining the landscape of biological research.

Testimonies

"Despite that we did not test each SLC in each platform, and we did not cover all available platforms, we can conclude that nano-antibodies were the best approach to generate SLC binders. Using this approach, we obtained the most robust binders fulfilling all our validation criteria."

ReSOLUTE Consortium

Research Empowerment on Solute Carriers

*all of the nano-antibodies in this study were provided by the NSF-UZH.

 

"Generation of nano-antibodies by immunization of alpaca at the Nano-antibody Service Facility of the UZH has been very valuable for leadXpro. We use the nano-antibodies directly or converted into Pro-Macrobodies as a tool to progress our membrane protein X-ray and cryo-EM structure projects. A big thank to the very competent work of the team of Saša Štefanić!"

Michael Hennig, CEO leadXpro

 

"I had the pleasure to work with Dr. Stefanic and the NSF with the ultimate goal of generating nano-antibodies targeting the cyst wall of Giardia lamblia, a parasite of global medical importance, as part of a UZH-funded project. The NSF provided all the support and advice needed for the successful completion of this project. Further input for follow-up experiments including nano-antibody production, validation and possible applications was also generously shared, beyond the call of duty. I am extremely satisfied with the service provided by the NSF and have warmly recommended it to colleagues at both UZH and UniBern where I currently lead my own group."

Prof. Dr. Carmen Faso

 

"Our research on bacterial pathogens greatly profits from NFS platform to conduct alpaca immunization at the University of Zurich. We highly appreciate the flexibility, reliablity and overall quality of the services provided by Saša Štefanić and his team."

Prof. Dr. Markus Seeger

 

Contact

Dr. Saša Štefanić

sasa.stefanic@uzh.ch

Tel.: +41 (0)52 354 91 28

Latest publication

Find out more about the role and function of the SPNS2 in new publication "Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2" by H. Z. Li, A. C. W. Pike, YN Chang et al.

The recombinant nano-antibodies developed by the NSF played a prominent role in the success of this collaborative effort.