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Nano-antibody Service Facility (NSF)

References

Publications citing NSF

Wirdnam CD, Schaerer T, Rubin M, Oberli A, Štefanić S, Hehl AB, Faso C. 
PLoS Negl Trop Dis. 2026 Mar 9;20(3):e0013844. doi: 10.1371/journal.pntd.0013844. PMID: 41801896; PMCID: PMC12970868.
Functionally-derivatized Nanoantibodies as novel tools for Giardia lamblia cyst detection
 
Daniel Yoon, Kamil Nosol, Ali Rasouli, Rose Bang-Sørensen, Rossitza N. Irobalieva, Hongtao Liu, Emad Tajkhorshid, Kaspar P. Locher
Structure, Volume 34, Issue 1, 2026, Pages 113-122.e7, ISSN 0969-2126, https://doi.org/10.1016/j.str.2025.09.012.
Structure of nanobody-inhibited state of human bile salt transporter NTCP
 
Di Palma Subran M, Wyss M, Taskoparan B, Maheswaran M, Berg JV, Plattet P, Chames P.
Mol Ther Oncol. 2025 Sep 8;33(3):201036. doi: 10.1016/j.omton.2025.201036. PMID: 41199882; PMCID: PMC12587322.
Nanobody-based canine PD-L1-targeting immune checkpoint inhibitors for cancer therapy in dogs
 
Sorgenfrei M, Hürlimann LM, Printz A, Wegner F, Morger D, Ackle F, Remy MM, Montowski G, Keserue HA, Cuénod A, Imkamp F, Egli A, Keller PM, Seeger MA.
Commun Biol. 2025 Jul 14;8(1):1047. doi: 10.1038/s42003-025-08345-9. PMID: 40659774; PMCID: PMC12259851.
Rapid detection and capture of clinical Escherichia coli strains mediated by OmpA-targeting nanobodies
 
Li, H.Z., Pike, A.C.W., Chang, YN. et al. 
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2. 
Nat Commun 16, 721 (2025). https://doi.org/10.1038/s41467-025-55942-7
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
 
Tomas C. Pascoa, Ashley C. W. Pike, Christofer S. Tautermann, Gamma Chi, Michael Traub, Andrew Quigley, Rod Chalk, Saša Štefanić, Sven Thamm, Alexander Pautsch, Elisabeth P. Carpenter, Gisela Schnapp & David B. Sauer 
Nat Struct Mol Biol. 2025 Mar;32(3):431-440. doi: 10.1038/s41594-024-01414-3. Epub 2024 Nov 11
Structural basis of the mechanism and inhibition of a human ceramide synthase
 
Zuzana Gelova, Alvaro Ingles-Prieto, et al.
Protein binder toolbox for studies of solute carrier transporters
Jounal of Molecular Biology, 2024. 168665, ISSN 0022-2836, https://doi.org/10.1016/j.jmb.2024.168665
 
Basavraj Khanppnavar, Joel P. S. Choo, Peter-Leon Hagedoorn, Grigory Smolentsev, Saša Štefanić, Selvapravin Kumaran, Dirk Tischler, Fritz K. Winkler, Volodymyr M. Korkhov, Zhi Li, Richard A. Kammerer & Xiaodan Li 
Nat. Chem. (2024). https://doi.org/10.1038/s41557-024-01523-y
Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase
 
Ved Mehta, Basavraj Khanppnavar, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M Korkhov.
Elife. 2022 Aug 18;11:e77032. doi: 10.7554/eLife.77032. PMID: 35980026; PMCID: PMC9433096.
 
Ramanadane K, Straub MS, Dutzler R, Manatschal C.
Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
Elife. 2022 Jan 10;11:e74589. doi: 10.7554/eLife.74589. PMID: 35001872; PMCID: PMC8806188.Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
 
Janine D Brunner, Roman P Jakob, Tobias Schulze, Yvonne Neldner, Anna Moroni, Gerhard Thiel, Timm Maier, Stephan Schenck
Elife, Apr 8, 2020, https://doi.org/10.7554/eLife.53683Structural basis for ion selectivity in TMEM175 K+ channels
 
Hundeep Kaur, Jean-Baptiste Hartmann, Roman P. Jakob, Michael Zahn, Iwan Zimmermann, Timm Maier, Markus A. Seeger & Sebastian Hiller 
J Biomol NMR 73, 375–384 (2019). https://doi.org/10.1007/s10858-019-00250-8Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach
 
Susanne Hofmann, Dovile Januliene, Ahmad R Mehdipour, Christoph Thomas, Erich Stefan, Stefan Brüchert, Benedikt T Kuhn, Eric R Geertsma, Gerhard Hummer, Robert Tampé, Arne Moeller 
Nature 571, 580–583 (2019). https://doi.org/10.1038/s41586-019-1391-0Conformation space of a heterodimeric ABC exporter under turnover conditions
 
Hutter CAJ, Timachi MH, Hürlimann LM, Zimmermann I, Egloff P, Göddeke H, Kucher S, Štefanić S, Karttunen M, Schäfer LV, Bordignon E, Seeger MA.
Nat Commun. 2019 May 21;10(1):2260. doi: 10.1038/s41467-019-09892-6. PMID: 31113958; PMCID: PMC6529423.
The extracellular gate shapes the energy profile of an ABC exporter
 
Schenck S, Kunz L, Sahlender D, Pardon E, Geertsma ER, Savtchouk I, Suzuki T, Neldner Y, Štefanić S, Steyaert J, Volterra A, Dutzler R.
Biochemistry. 2017 Aug 1;56(30):3962-3971. doi: 10.1021/acs.biochem.7b00436. Epub 2017 Jul 21. PMID: 28731329.

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport

 
Mireku SA, Sauer MM, Glockshuber R, Locher KP
Sci Rep. 2017 Oct 30;7(1):14296. doi: 10.1038/s41598-017-14512-8. PMID: 29084999; PMCID: PMC5662663.Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD